Commodore Matthew Perry sailed into Tokyo Bay on this date in 1853 and and he parked himself at the mouth of the bay, the big guns he carried trained on the city of Uraga. He insisted that he be allowed to deliver a letter to the emperor.
The Japanese demanded that he remove himself to Nagasaki, far down the coast, where Dejima Island had been created for the exclusive use of foreigners. All foreigners, though at the moment most of its inhabitants were representatives of the Dutch East India Company and a few Chinese traders.
The rest of Japan was closed to outsiders and had been for centuries.
Nothing doing, was Perry’s response. He had a letter to the Emperor from his president and it better get delivered. The Japanese, who represented the Shogun and had nothing to do with the emperor, agreed to deliver the letter.
Perry sailed away towards China, but sailed back a few months later. He had more ships with him. but the Shogun had agreed to all of his demands and a treaty was signed.
Sakoku – the official policy of isolationism – had ended. Bakumatsu – the end of the curtain – had begun.

japanese portrait of Perry.
Perry’s tactics had been well thought out, based on the experiences of previous Westerners who had tried to get past the Dejima Island restriction and failed. Before he sailed east, he studied up on all the history of the country and even made a point of corresponding with Philipp Franz von Seibold, the world’s leading expert on the subject of Japan.
The story of von Seibold is much more interesting than Perry’s, actually. A military doctor and botanist, von Seibold had been sent to Dejima by the Dutch East India Company in 1823 and stayed eight years. In that time he collected thousands of samples of the flora and fauna of the country (his servants brought samples to the island for him), as well as objects given as payment for his medical services.
He collected enough stuff to create a herbarium in Holland (now part of the University of Leiden), to start a National Museum of Ethnology (in his house in Leiden) and to inspire similar institutions in Japan. He is not only well–known in Europe, but he is so famous in Japan that Seibold University of Nagasaki was not only named for him, but opened on the 175th anniversary of his arrival there.

Otaki Kusumoto, von Seibold's wife
von Seibold had to leave his Japanese wife and daughter behind when he left (in disgrace – he was accused by the shogun of stealing maps of the country) and didn’t return for 30 years. By that time, his daughter had grown up, been educated as a physician by Seibold’s successor and become the first woman doctor in Japan to practice western medicine.
He only lasted three years the second time around, infuriating his Dutch employers who again sent him home. After that, he focused on the study of his botanical specimens until his death. We have Seibold to thank, btw, for the hosta. Gardeners will no doubt recognize his name from the scores of plants labeled seiboldi or seiboldiana.
Much more about him can be found here. Below, the small island in the foreground is Dejima, in Nagasaki Bay.

Dejima Island in Nagasaki Bay.